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KMID : 0858620060100020150
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Korean Journal of Audiology
2006 Volume.10 No. 2 p.150 ~ p.156
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Expression of Interleukin-1 Alpha and Tumor Necrosis Factor-alpha Related to the Degree of Bone Resorption in Aural Cholesteatoma
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Kim Hae-Young
Chun Jin-Hyung
Hong Hyung-Jeong
Kim Hyung-Jong
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Abstract
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Background and Objectives: Cytokines are reported to play an important role in bone resorptive process in chronic otitis media with or without aural cholesteatoma. The object of this study was to measure quantitatively the expression of interleukin-1 alpha (IL-1α) and tumor necrosis factor-alpha (TNF-α) with regard to the degree of bone resorption occured in chronic otitis media.
Materials and Methods: Eighteen cholesteatomas and fourteen mucosa granulation tissues were collected from chronic otitis media with or without cholesteatoma. The degree of bone resorption was classified clinically using with radiologic and operation findings. The activities of IL-1α and TNF-α were measured by enzyme-linked immunosorbent assay. As control group, deep external auditory canal skins were collected from seven patients. ANOVA test was used for comparisons among the groups (p<0.05).
Results: The levels of IL-1α and TNF-α in cholesteatoma were significantly greater than those in non-cholesteatoma group and control group. In addition, there were also significant differences of these cytokine levels between the group of chronic otitis media with bone resorption and the group without bone resorption.
Conclusion: Cytokines may play a role in the bone resorption in aural cholesteatoma.
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KEYWORD
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Cholesteatoma, Cytokine, Bone resorption
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